The Polytechnic Museum is one of the largest scientific and technical museums in the world. The Association of Natural Science, Anthropology, and Ethnography Enthusiasts initiated its formation on the basis of funds from the 1872 Polytechnic Fair.

Over the course of its history, the Polytechnic Museum has helped popularise ideas and solutions crucial for scientific and technical progress. It meticulously collects and stores devices and objects associated with the development of technical thinking.

At the moment, the historical building of the Museum is closed for reconstruction until 2020. During this period, the Polytech is open at three separate venues: Their new exhibition Russia Does It on Its Own is open at VDNH, the Moscow technopolis houses the Open Collections, and the Polytechnic Library and Scientific Labs are open to the public at the ZIL Cultural Centre.