City officials in search for new approaches and instruments to govern are coming to complex understandings of the nature of health. A research study looked at the best methods of governance, instruments and mechanisms that allow megapolises to effectively respond to key health problems and find new trajectories of growth to prolong the life of urban citizens. Rankings of leading megacities of the world in the sphere of Urban Health, with respect to dynamics of health in the city. Results of this study became recommendations for Moscow on how to develop instruments of governance and also in understanding the practical possibilities and programs to improve Health in the Megapolis.